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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK2
All Species:
18.18
Human Site:
S139
Identified Species:
28.57
UniProt:
Q92630
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92630
NP_003574.1
601
66652
S139
R
R
Q
G
S
S
T
S
L
K
S
M
E
G
M
Chimpanzee
Pan troglodytes
XP_509205
601
66595
S139
R
R
Q
G
S
S
T
S
L
K
S
M
E
G
M
Rhesus Macaque
Macaca mulatta
XP_001117134
601
66643
S139
R
R
Q
G
S
S
T
S
L
K
S
M
E
G
M
Dog
Lupus familis
XP_538273
601
66656
S139
R
R
Q
G
S
S
T
S
L
K
S
M
E
G
M
Cat
Felis silvestris
Mouse
Mus musculus
Q5U4C9
599
66538
M162
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
Rat
Rattus norvegicus
Q4V8A3
586
65492
Q148
T
P
E
Q
A
L
K
Q
Y
K
H
H
L
T
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
Y149
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
Chicken
Gallus gallus
Q5ZIU3
526
59419
I136
D
D
D
Q
G
S
Y
I
Q
V
P
H
D
H
I
Frog
Xenopus laevis
NP_001088793
567
63329
S146
L
Q
E
I
S
S
F
S
E
I
H
F
V
G
P
Zebra Danio
Brachydanio rerio
NP_001038298
587
65453
Q149
T
P
E
Q
A
M
K
Q
Y
M
S
K
L
S
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
S193
F
H
E
Q
I
I
M
S
G
Q
Q
K
C
E
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023208
796
87422
G378
S
H
T
S
S
S
G
G
S
Q
G
G
H
N
S
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
S140
L
Y
M
H
K
L
T
S
Y
E
H
H
E
I
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
V77
S
G
L
V
P
N
F
V
Y
P
N
M
F
Y
N
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
N286
N
D
L
Q
P
V
L
N
A
T
P
K
F
R
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
99.6
98.3
N.A.
97
59.7
N.A.
78.6
81.3
64.5
83.6
N.A.
43.3
N.A.
45.7
63.7
Protein Similarity:
100
98.8
99.8
99
N.A.
98.5
71.8
N.A.
83
84.5
75
89.8
N.A.
54.9
N.A.
55.6
73.5
P-Site Identity:
100
100
100
100
N.A.
6.6
6.6
N.A.
0
6.6
26.6
6.6
N.A.
6.6
N.A.
13.3
20
P-Site Similarity:
100
100
100
100
N.A.
13.3
20
N.A.
6.6
20
40
26.6
N.A.
26.6
N.A.
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.3
27.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
36.6
41.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
14
0
0
0
7
0
0
0
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% C
% Asp:
7
14
7
0
0
0
0
0
7
7
7
0
7
0
0
% D
% Glu:
7
0
27
0
0
0
0
0
7
7
0
0
34
7
7
% E
% Phe:
7
0
0
0
0
0
14
0
0
0
0
7
14
7
7
% F
% Gly:
7
14
0
27
7
7
14
7
7
0
7
7
7
34
0
% G
% His:
0
14
0
7
0
0
0
0
0
0
20
20
7
7
0
% H
% Ile:
0
0
0
7
7
7
0
7
0
7
0
0
0
7
7
% I
% Lys:
0
0
0
0
14
0
14
0
0
40
0
20
0
0
0
% K
% Leu:
14
0
14
0
0
14
7
0
27
0
7
0
14
0
7
% L
% Met:
0
0
7
7
0
7
7
7
0
7
0
34
0
0
27
% M
% Asn:
7
0
0
7
7
7
0
7
0
0
7
0
0
7
7
% N
% Pro:
0
14
7
0
14
0
0
0
0
7
14
0
0
0
7
% P
% Gln:
0
14
27
34
0
7
0
14
14
14
7
7
0
0
0
% Q
% Arg:
27
27
0
0
0
0
0
0
0
0
0
0
0
7
7
% R
% Ser:
14
0
0
7
40
47
0
47
7
0
34
0
0
14
7
% S
% Thr:
14
0
7
0
0
0
34
0
0
7
0
7
0
7
0
% T
% Val:
0
0
0
7
0
7
0
7
0
7
0
0
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
14
7
27
0
0
0
0
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _